�New brainwave into the way in which inflammatory cells known as macrophages leave the blood and access sites of trauma has been provided by Jane Hoover-Plow and colleagues, at Cleveland Clinic Lerner Research Institute, Cleveland, world Health Organization studied the process in mice. This information has particular clinical relevance to injury and inflammation of the major arterial blood vessels, matchless of the main causes of spunk attack and stroke.
It was plant that in mice absent a protein known as plasminogen, macrophages were less able to leave the blood and access sites of injury than in normal mice. This was associated with decreased activation of a protein known as MMP-9, and addition of MMP-9 to the mice restored the ability of macrophages to access sites of injury.
As this was also true in a mouse theoretical account of abdominal muscle aortic aneurism (AAA), a chronic degenerative condition of the aorta that is usually fateful if it ruptures, the authors indicate that targeting the plasminogen/MMP-9 pathway mightiness be a viable coming to controlling disease-causing inflammation, such as occurs in the development of AAA.
"Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice"
Yanqing Gong, Erika Hart, Aleksey Shchurin and Jane Hoover-Plow
J. Clin. Invest. doi:10.1172/JCI32750.
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The Journal of Clinical Investigation (JCI) is the issue of the American Society for Clinical Investigation, an honor fellowship of physician-scientists.
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